The subcommittee epidemiologist created a detailed content outline, which was reviewed and approved by the subcommittee.
The outline contained a list of primary and secondary topics generated to guide a thorough literature search and meet the goal of providing an up-to-date systemic review of the literature pertaining to the diagnosis, management, and treatment of pediatric HTN as well as the prevalence of pediatric HTN and its associated comorbidities.
Of the topics covered in the outline, ∼80% were researched by using a Patient, Intervention/Indicator, Comparison, Outcome, and Time (PICOT) format to address the following key questions: To address these key questions, a systematic search and review of literature was performed.
The initial search included articles published between the publication of the Fourth Report (January 2004) and August 2015.
High BP is consistently greater in boys (15%–19%) than in girls (7%–12%).
The prevalence of high BP is higher among Hispanic and non-Hispanic African American children compared with non-Hispanic white children, with higher rates among adolescents than among younger children.
(See Table 1 for a complete list of KASs.)A detailed description of the methodology used to conduct the literature search and systematic review for this clinical practice guideline will be included in the forthcoming technical report.
In brief, reference selection involved a multistep process.
Special working groups were created to address 2 specific topics for which evidence was lacking and expert opinion was required to generate KASs, “Definition of HTN” and “Definition of LVH.” References for any topics not covered by the key questions were selected on the basis of additional literature searches and reviewed by the epidemiologist and subcommittee members assigned to the topic.
When applicable, searches were conducted by using the PICOT format .
First, 2 subcommittee members reviewed the titles and abstracts of references identified for each key question.